There are a number of solutions for rendering “non-standard” web fonts on your site. I was familiar with ones like SIFR and Cufon where it’s recommend to be used only on headers or certain spots of the website. I e-mailed TypeKit to see if it worked the same way, and got this reply from Mandy Brown:
“There’s no file size or speed issue with using Typekit for body text (as there would be with, say, using SIFR or Cufon). That said, you should make sure to use a font that works well at small sizes and renders acceptably cross-browser. Be sure to take a look at the browser screenshots before deciding on a font.”
Oddly, Google failed me on this question, so I thought I’d post it here for anyone else who was curious.